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Approved research

The association of vascular and systemic inflammation with cerebrovascular diseases and its related outcomes

Principal Investigator: Dr Yan Liang
Approved Research ID: 59117
Approval date: June 4th 2020

Lay summary

Inflammation has been implicated as a risk factor for cerebrovascular diseases. There are evidences that anti-inflammatory drugs potentially improve stroke outcomes. However, several key questions shall be addressed to further understand the causal association of inflammation with cerebrovascular diseases. First, although there exist evidences supporting causal relationship between inflammation and stroke, the association between the genetic predisposition to either systemic and vascular inflammation and the related outcomes of stroke are unknown. Second, the causal relationship between inflammation and SVD/carotid stenosis are rarely studied. Last, previous studies did not comprehensively examine the role of both vascular and systemic inflammation in developing cerebrovascular diseases. It is unclear how the inflammation mediates or moderates the cerebrovascular outcomes such dementia, recurrence of stroke or mortality. The project primarily aims to investigate the association between vascular and systemic inflammation and cerebral vascular diseases including stroke, cerebral small vessel diseases and carotid stenosis. Particularly, the study is set to explore the causal relationship between the genetically determined circulating levels of inflammatory biomarkers (homocysteine, neopterin, ICAM-1, VCAM-1, E-selectin, P-selectin, VEGF, CRP, IL-6, TNF-!, fibrinogen, etc), genetic underpinnings relating to susceptibility of infection and immunoinflammatory diseases and the cerebrovascular diseases. Last, the study observes the mediating or moderating effects of inflammation on the vascular outcomes. This project is expected to last for 36 months. The findings may deepen the understanding in biological mechanisms of cerebrovascular and their related outcomes, and may guide anti-inflammatory strategies to prevent and treat cerebrovascular diseases.