Some subjects are exposed to coronavirus, yet they remain uninfected. And most of COVID-19 patients are not seriously ill. It is possible that at least part of this difference may be able to explain by the genetic variation between individuals. We aim to find out the association between genetic variants and COVID-19. This genome-wide association studies provide a chance to better understand the effect of genetic variants on COVID-19, and ultimately help to develop effective preventive and Therapeutic targets of COVID-19.