Epidemiologic and genetic analyses of aging-associated diseases and mortality
Lay summaryThe aim of this project is to identify the potentially modifiable risk factors, such as diet, lifestyle, hormonal, and anthropometric measures, and genetic factors for aging-associated diseases and premature death. To provide insights into biological mechanisms that may link the exposures to disease risk, we will investigate potential mediating roles of biomarkers and blood pressure and other measures on the associations between exposures and disease outcomes. We will also investigate gene-environment interactions and use Mendelian randomisation to determine causality of the exposure-disease relationships. Findings from this project will increase our understanding of the aetiology of aging-associated diseases. This research could lead to improved ability to identify individuals at increased risk of aging-associated diseases and possibly tailored treatment strategies accounting for genetic background. We will conduct epidemiological analyses of the associations of potential risk factors with incidence of aging-associated diseases as well as all-cause and cause-specific mortality. Furthermore, we will perform Mendelian randomisation analyses using genetic variants as proxies for the exposures. We will also use the available genetic data and environmental measures (e.g., diet, lifestyle and anthropometry) to study gene-environment interactions. We plan to use the full cohort.
- Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank: a Mendelian randomization study
- Thyroid Function and Dysfunction in Relation to 16 Cardiovascular Diseases : A Mendelian Randomization Study
- Insulin-like growth factor-1 and site-specific cancers: A Mendelian randomization study
- Smoking, alcohol consumption, and cancer: A mendelian randomisation study in UK Biobank and international genetic consortia participants
- Is Type 2 Diabetes Mellitus Causally Associated with Cancer Risk? Evidence From a Two-Sample Mendelian Randomisation Study.
- Genetic predisposition to smoking in relation to 14 cardiovascular diseases.
- Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study
- Smoking, alcohol consumption and cancer: A Mendelian randomisation study in UK Biobank and international genetic consortia participants
- Genetically predicted circulating B vitamins in relation to digestive system cancers
- Genetically Proxied Inhibition of Coagulation Factors and Risk of Cardiovascular Disease: A Mendelian Randomization Study
- Genetic liability to insomnia in relation to cardiovascular diseases: a Mendelian randomisation study
- Dose–response relationship between genetically proxied average blood glucose levels and incident coronary heart disease in individuals without diabetes mellitus
- Genetically proxied milk consumption and risk of colorectal, bladder, breast, and prostate cancer: a two-sample Mendelian randomization study
- Genetically predicted plasma phospholipid arachidonic acid concentrations and 10 site-specific cancers in UK biobank and genetic consortia participants: A mendelian randomization study
- Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study