Skip to navigation Skip to main content Skip to footer

Approved research

Association of melanoma and non-melanoma skin cancers with the interaction between lifestyle and genetic factors

Principal Investigator: Dr Hong Liu
Approved Research ID: 55257
Approval date: June 12th 2020

Lay summary

We aim to investigate the impact of lifestyle, genetic factors and their interaction with the incidence of skin cancers. Previous literature has suggested that physical activity is protective against various cancer types in both smokers and non-smokers. However, systemic exploration of how the beneficial influence of physical activity might be attenuated or strengthened by genetic background is limited. With the large sample size of UK Biobank, we will have sufficient power to characterize this potential interaction. In addition, blood biochemistry markers have been a proxy for organ function and widely used in the clinic. We would like to investigate whether these markers can be used to inform the interaction between lifestyle factors and genetic composition.