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Application of machine learning methodologies on the UK biobank dataset to quantify the effect of lifestyle habits on health

Application of machine learning methodologies on the UK biobank dataset to quantify the effect of lifestyle habits on health

Principal Investigator: Dr Pinchas Akiva
Approved Research ID: 58770
Approval date: March 27th 2020

Lay summary

The primary aim of this project is to utilize the large data set available in the UK biobank to establish a quantitative association between the lifestyle behavior (e.g. diet, fitness activity, smoking habits, stress, etc.) of the subjects and their health status. The association between specific lifestyle behaviors and chronic diseases is widely studied (e.g. sedentary lifestyle and cardiovascular disease risk, consumption of processed meat and cancer, etc.). However, quantifying such risks according to lifestyle behavior remains a challenge, as well as measuring the combined effect of multiple behaviors on multiple outcomes. By analyzing data of the entire UK Biobank cohort, including lifestyle questionnaire data, primary care records, and additional clinical data records, we will construct multiple machine learning models tailored to predicting a wide set of disease risks. In addition, we plan to study the association of lifestyle behaviors to diseases through clinical biomarkers (e.g. CRP, ESR, glucose, albumin, BMI, TG, cholesterol, BP, etc.). This will allow us to study how lifestyle behavior affects the clinical biomarkers, and how these biomarkers can be used for health status evaluation (i.e. how clinical biomarkers mediate the association between lifestyle behavior and clinical status). We will undertake this research using anonymous data. The project will last 18 months.

The high impact of this study stems from its ability to influence a very wide population. An ability to better understand and quantify the effect of lifestyle behavior on health has the potential to allow choosing the most fitting change, considering the personalized impact on the individual's health. This project will potentially expand the public knowledge concerning lifestyle habits and their impact on disease risk, and will also contribute to the creation of models that will better allow assessing and improving health, thus avoiding major health complications in the future.